Dr. Lenz: Genetic Signature Not Helpful to Predict Recurrence in Clinical Practice

At ASCO 2009 Dr. David Kerr from the United Kingdom presented data on a genetic signature which is associated with tumor recurrence in stage II colon cancer. However these data are not even close to being clinically meaningful.

These data have been discussed by Kate Murphy. However I wanted to follow up with the significance of the data. To increase the risk of recurrence from 12% to 22% is not in any way or form helpful in the clinic, particularly because this outcome is independent of treatment effect. Continue reading…

Posted by Heinz-Josef Lenz, MD on June 25th, 2009
Posted in: From the Desk of Dr. Lenz | No Comments »
Tags: ASCO 2009, genetic signature, recurrence risk, Understanding Genetics

ASCO Research Highlights: Molecular Markers in Stage II and III Colon Cancer

Several studies presented at ASCO looked a biomarkers that might predict cancer recurrence or patient survival in stage II and III colon cancer and whether patients could be chosen to receive chemotherapy based on those markers.  Of special interest was the hypothesis offered by two researchers from the PETACC-3 clinical trial that stage II and stage III may be very different biologically.  As Dr. Arnaud Roth said, “. . .in other words, could be different diseases.” Continue reading…

Posted by Kate Murphy on June 12th, 2009
Posted in: Research & Treatment News | 1 Comment »
Tags: ASCO 2009, molecular markers, stage II colon cancer, stage III colon cancer

MSI in Stage II Colon Cancer: Chemotherapy or Not?

Some of the most interesting data presented at ASCO was the data on MSI and 18qLOH in a European clinical trial.

Last year at ASCO, Dr. Daniel Sargent presented new data that patients with stage II disease with microsatellite instability do not only not benefit from 5-FU, but they may be harmed, and it was recommended to test for MSI in all stage II colon cancer patients and in the presence of MSI-high not to give 5-FU. For stage III colon cancer that was not the case.

This year, the PETACC-3 clinical trial was analyzed for MSI and did not show the same the same findings. It seems that chemotherapy does not harm these patients, and they may benefit. Continue reading…

Posted by Heinz-Josef Lenz, MD on June 8th, 2009
Posted in: From the Desk of Dr. Lenz | 6 Comments »
Tags: 18qLOH, ASCO 2009, MSI, personalized medicine, Understanding Genetics

Avastin in Stage II and III Colon Cancer

In the plenary session at ASCO this year there was a presentation of a large NASBP trial which tested whether the addition of Avastin® (bevacizumab) to 6 months of FOLFOX would decrease tumor recurrence.

The data suggested that there was no benefit with the addition of Avastin, which was given not only for 6 months along with chemotherapy but 6 months in addition to FOLFOX for a total of 12 months. Continue reading…

Posted by Heinz-Josef Lenz, MD on June 7th, 2009
Posted in: From the Desk of Dr. Lenz | 5 Comments »
Tags: adjuvant chemotherapy, ASCO 2009, Avastin, Treating Colorectal Cancer

Primary Colorectal Tumors Can Be Safely Left in Place

When cancer has spread beyond the colon or rectum, the primary colorectal tumor can safely be left in place with only rare complications.

Surgeons at Memorial Sloan Kettering Cancer Center in New York followed 233 patients who began chemotherapy without surgery to remove their primary colon or rectal tumor. Almost 90 percent never had a problem with their tumor that needed intervention with surgery, radiation, or a stent. Only 7 percent required emergency surgery. Continue reading…

Posted by Kate Murphy on June 7th, 2009
Posted in: Research & Treatment News | No Comments »
Tags: ASCO 2009, metastatic colorectal cancer, surgery